(2E)-3-{3-[(4-Bromo-1H-pyrazol-1-yl)methyl]-4-methoxyphenyl}acrylic acid
(2E)-3-{3-[(4-Bromo-1H-pyrazol-1-yl)methyl]-4-methoxyphenyl}acrylic acid
CAS: 1020050-93-4
Molecular Formula: C14H13BrN2O3
(2E)-3-{3-[(4-Bromo-1H-pyrazol-1-yl)methyl]-4-methoxyphenyl}acrylic acid - Names and Identifiers
(2E)-3-{3-[(4-Bromo-1H-pyrazol-1-yl)methyl]-4-methoxyphenyl}acrylic acid - Physico-chemical Properties
| Molecular Formula | C14H13BrN2O3 |
| Molar Mass | 337.17 |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD06801426 |
(2E)-3-{3-[(4-Bromo-1H-pyrazol-1-yl)methyl]-4-methoxyphenyl}acrylic acid - Introduction
(2E)-3-{3-[() methyl]-4-methyphenyl} acrylic acid, also known as (2E)-3-{3-[(4-bromo-1H-pyrazol-1-yl) methyl-4-methoxyphenyl} acrylic acid, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Chemical formula: C14H12BrN3O3
-Molecular weight: 355.17g/mol
-Appearance: Colorless crystal or powder solid
-Melting point: about 230-232°C
-Solubility: Soluble in organic solvents such as methanol, dichloromethane and ethyl acetate, insoluble in water.
Use:
(2E)-3-{3-[(methyl)]-4-methoxyphenyl}acrylic acid is commonly used as an intermediate in organic synthesis and has the following uses:
-As a drug intermediate: It can be used to synthesize biologically active compounds, such as anti-cancer drugs, antibacterial drugs, etc.
-as a dye intermediate: can be used for the synthesis of azicyanine and other dyes.
Preparation Method:
(2E)-3-{3-[(methyl)]-4-methoxyphenyl}acrylic acid can be prepared as follows:
1. First, (4-bromo-1H-pyrazol-1-yl) methylbenzaldehyde is synthesized under appropriate reaction conditions.
2. Condensation reaction of the synthesized (4-bromo-1H-pyrazol-1-yl) methylbenzaldehyde with methyl p-toluenesulfonate to obtain (2E)-3-{3-[(4-bromo-1H-pyrazol-1-yl) methyl]-4-methoxyphenyl} propenal.
3. Finally, (2E)-3-{3-[(4-bromo-1H-pyrazol-1-yl) methyl]-4-methoxyphenyl} propenal is subjected to an oxidation reaction to produce the final product (2E)-3-{3-[(4-bromo-1H-pyrazol-1-yl) methyl]-4-methoxyphenyl} acrylic acid.
Safety Information:
The following safety precautions are required when handling and using (2E)-3-{3-[(4-bromo-1H-pyrazol-1-yl) methyl]-4-methoxyphenyl} acrylic acid:
-The compound may cause irritation and damage to the human body. Wear chemical protective gloves, goggles, etc. during operation. Avoid inhalation, contact with skin and entering eyes.
-Operate in a well-ventilated place to avoid dust and vapor.
-Storage should be sealed to avoid contact with oxygen and moisture.
-Follow relevant safe practices and standard procedures for the use of chemicals.
Nature:
-Chemical formula: C14H12BrN3O3
-Molecular weight: 355.17g/mol
-Appearance: Colorless crystal or powder solid
-Melting point: about 230-232°C
-Solubility: Soluble in organic solvents such as methanol, dichloromethane and ethyl acetate, insoluble in water.
Use:
(2E)-3-{3-[(methyl)]-4-methoxyphenyl}acrylic acid is commonly used as an intermediate in organic synthesis and has the following uses:
-As a drug intermediate: It can be used to synthesize biologically active compounds, such as anti-cancer drugs, antibacterial drugs, etc.
-as a dye intermediate: can be used for the synthesis of azicyanine and other dyes.
Preparation Method:
(2E)-3-{3-[(methyl)]-4-methoxyphenyl}acrylic acid can be prepared as follows:
1. First, (4-bromo-1H-pyrazol-1-yl) methylbenzaldehyde is synthesized under appropriate reaction conditions.
2. Condensation reaction of the synthesized (4-bromo-1H-pyrazol-1-yl) methylbenzaldehyde with methyl p-toluenesulfonate to obtain (2E)-3-{3-[(4-bromo-1H-pyrazol-1-yl) methyl]-4-methoxyphenyl} propenal.
3. Finally, (2E)-3-{3-[(4-bromo-1H-pyrazol-1-yl) methyl]-4-methoxyphenyl} propenal is subjected to an oxidation reaction to produce the final product (2E)-3-{3-[(4-bromo-1H-pyrazol-1-yl) methyl]-4-methoxyphenyl} acrylic acid.
Safety Information:
The following safety precautions are required when handling and using (2E)-3-{3-[(4-bromo-1H-pyrazol-1-yl) methyl]-4-methoxyphenyl} acrylic acid:
-The compound may cause irritation and damage to the human body. Wear chemical protective gloves, goggles, etc. during operation. Avoid inhalation, contact with skin and entering eyes.
-Operate in a well-ventilated place to avoid dust and vapor.
-Storage should be sealed to avoid contact with oxygen and moisture.
-Follow relevant safe practices and standard procedures for the use of chemicals.
Last Update：2024-04-09 21:01:54
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(2E)-3-{3-[(4-Bromo-1H-pyrazol-1-yl)methyl]-4-methoxyphenyl}acrylic acid
Ersentilide [inn]
[1,1'-Biphenyl]-3-carboxylic acid, 3'-chloro-5'-hydroxy-
N-((E)-1-[2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOL-5-YL]ETHYLIDENE)-N-[(CYCLOPROPYLCARBONYL)OXY]AMINE
5-(4-bromophenyl)-2-furaldehyde [2,6-di(4-morpholinyl)-4-pyrimidinyl]hydrazone
Imatinib Impurity D
1-[4-(BENZYLOXY)-2'-CHLORO[1,1'-BIPHENYL]-3-YL]ETHANONE
6-amino-4-{4-methoxy-3-[(2-pyridinylsulfanyl)methyl]phenyl}-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
Formamide, N-[(chlorodimethylsilyl)methyl]-N-phenyl-
16874-08-1
Ersentilide [inn]
[1,1'-Biphenyl]-3-carboxylic acid, 3'-chloro-5'-hydroxy-
N-((E)-1-[2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOL-5-YL]ETHYLIDENE)-N-[(CYCLOPROPYLCARBONYL)OXY]AMINE
5-(4-bromophenyl)-2-furaldehyde [2,6-di(4-morpholinyl)-4-pyrimidinyl]hydrazone
Imatinib Impurity D
1-[4-(BENZYLOXY)-2'-CHLORO[1,1'-BIPHENYL]-3-YL]ETHANONE
6-amino-4-{4-methoxy-3-[(2-pyridinylsulfanyl)methyl]phenyl}-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
Formamide, N-[(chlorodimethylsilyl)methyl]-N-phenyl-
16874-08-1